The #1 Lawyer by Jas Patterson and Nancy Allen

 Stafford Lee is an attorney in Biloxi, Mississippi who has an unbroken string of wins. But he's a little worried that his current case might be his first loss. A doctor is accused of murdering a patient he had been sleeping with--who happens to be the niece of the DA. When that case ends, Stafford finds himself being arrested for the murder of the doctor's wife. There were lots of twists and turns along the way as Stafford and his intrepid PI, Jenny, try to figure out who the real killer was in the original case--and who is trying to frame him in the second case.